Newly Developed Rat Model of Chronic Kidney Disease–Mineral Bone Disorder
نویسندگان
چکیده
منابع مشابه
Newly Developed Rat Model of Chronic Kidney Disease–Mineral Bone Disorder
AIM Chronic kidney disease-mineral bone disorder (CKD-MBD) is associated with all-cause and cardiovascular morbidity and mortality in patients with CKD. Thus, elucidating its pathophysiological mechanisms is essential for improving the prognosis. We evaluated characteristics of CKD-MBD in a newly developed CKD rat model. METHODS We used male Sprague-Dawley (SD) rats and spontaneously diabetic...
متن کاملA rat model of chronic kidney disease-mineral bone disorder.
Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is a newly defined syndrome encompassing patients with chronic kidney disease that have a triad of biochemical alterations in calcium, phosphorus and parathyroid hormone, vascular calcification, and bone abnormalities. Here we describe a novel Cy/+ rat model of slowly progressive kidney disease spontaneously developing the three components ...
متن کاملChronic Kidney Disease-Mineral and Bone Disorder
1Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan 2Centre for Nephrology & Urology, Department of Physiology, Shenzhen University Health Science Center, Shenzhen, China 3Centre for Nephrology, University College London, London, UK 4Centre for Cardiovascular Science, Queen’s Medical Re...
متن کاملA Rat Model of Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) and The Effect of Dietary Protein Source
Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is a newly defined disorder that describes the interacting triad of (1) biochemical abnormalities of calcium, phosphorus, and PTH, (2) vascular calcification, and (3) abnormal bone in patients with CKD. We describe a novel animal model of slowly progressive CKD that spontaneously develops all three components of CKD-MBD while fed a normal p...
متن کاملR-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD).
BACKGROUND Chronic kidney disease-mineral bone disorder (CKD-MBD), a newly defined disorder in patients with CKD, describes the interacting triad of (1) biochemical abnormalities of calcium, phosphorus and parathyroid hormone (PTH), (2) extraskeletal calcification and (3) abnormal bone. METHODS We studied the effects of the calcimimetic R-568, R-568 with calcium (R-568 + Ca) or calcium (Ca) a...
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ژورنال
عنوان ژورنال: Journal of Atherosclerosis and Thrombosis
سال: 2018
ISSN: 1340-3478,1880-3873
DOI: 10.5551/jat.40170